资源类型

期刊论文 861

会议视频 87

年份

2024 1

2023 36

2022 81

2021 60

2020 27

2019 22

2018 51

2017 60

2016 55

2015 54

2014 51

2013 34

2012 29

2011 53

2010 41

2009 26

2008 41

2007 51

2006 40

2005 29

展开 ︾

关键词

能源 18

颠覆性技术 15

战略研究 14

发展战略 10

农业科学 9

研究进展 8

信息技术 7

医学 7

人工智能 6

智能制造 6

环境 6

可持续发展 5

工程管理 5

城镇建设 4

战略 4

技术预见 4

指标体系 4

数值模拟 4

生态文明 4

展开 ︾

检索范围：

排序： 展示方式：

Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

《医学前沿（英文）》 2011年 第5卷 第4期   页码 333-335 doi: 10.1007/s11684-011-0166-2

摘要： Cell therapy holds promise in addressing a number of unmet medical needs but despite its considerable impetus, faces numerous challenges including support for translational research in this area. Here, we examine the challenges confronting cell therapy research including the limited funding available for translational research partly due to the uncompetitive nature of required validation studies in cell therapy that of necessity are not hypothesis-driven. Other issues include lack of standardization of definitions of cell products, uncertainty regarding optimum preclinical animal models, duplication of efforts to secure regulatory approval and a lack of uniformity of nomenclature for some cell products. Nonetheless, several initiatives to address all of these issues are underway.

关键词： stem cells     clinical trials     funding     animal models     standardization     common definitions    

HTML PDF 收藏

Translational research on novel drug-eluting stents in percutaneous coronary intervention

Yaling Han, Kai Xu, Chenghui Yan

《医学前沿（英文）》 2011年 第5卷 第4期   页码 395-400 doi: 10.1007/s11684-011-0167-1

摘要： Although first-generation drug-eluting stents (DES) have markedly reduced restenosis, complications of late and very late in-stent thrombosis have emerged as prime limitations to this technology. The development of new DES is a key process to prevent these complications. Translational research plays a very important role in experiments which determine the safety and efficacy of DES before human clinical trials. The present review focuses on translational research of novel DES, including drug discovery, creation of preclinical research models, planning and conducting of first-in-man studies, and developing next-generation DES systems.

关键词： translational research     drug-eluting stents     percutaneous coronary intervention    

HTML PDF 收藏

Error analysis and optimization of a 3-degree of freedom translational Parallel Kinematic Machine

null

《机械工程前沿（英文）》 2014年 第9卷 第2期   页码 120-129 doi: 10.1007/s11465-014-0300-3

摘要：

In this paper, error modeling and analysis of a typical 3-degree of freedom translational Parallel Kinematic Machine is presented. This mechanism provides translational motion along the Cartesian X-, Y- and Z- axes. It consists of three limbs each having an arm and forearm with prismatic-revolute-revolute-revolute joints. The moving or tool platform maintains same orientation in the entire workspace due to its joint arrangement. From inverse kinematics, the joint angles for a given position of tool platform necessary for the error modeling and analysis are obtained. Error modeling is done based on the differentiation of the inverse kinematic equations. Variation of pose errors along X, Y and Z directions for a set of dimensions of the parallel kinematic machine is presented. A non-dimensional performance index, namely, global error transformation index is used to study the influence of dimensions and its corresponding global maximum pose error is reported. An attempt is made to find the optimal dimensions of the Parallel Kinematic Machine using Genetic Algorithms in MATLAB. The methodology presented and the results obtained are useful for predicting the performance capability of the Parallel Kinematic Machine under study.

关键词： translational Parallel Kinematic Machine     error modeling     global error transformation index    

HTML PDF 收藏

Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)

ZHAI Wenjie, LIU Changxiong, LIANG Yingchun

《机械工程前沿（英文）》 2008年 第3卷 第4期   页码 441-448 doi: 10.1007/s11465-008-0074-6

摘要： By keeping a pad moving relative to a wafer along a circular path without rotation, we developed a polishing technique called circular-translational-moving polishing (CTMP), which permits multidirectional polishing of the work piece and thus bears the advantage of isotropic polishing and a potential increase of material removal rate (MRR) on the wafer. To illuminate the mechanisms of CTMP and determine the optimum process variables in a CTMP process, a three-dimensional hydrodynamic lubrication model for CTMP with a smooth and rigid pad under a quasi-stable state is established in a polar coordinate system. The model equations are further calculated numerically by the finite difference method. The instantaneous distribution of fluid pressure is obtained, which shows that a negative pressure exists. The reason for negative pressure in CTMP and its effect on polishing is discussed. Moreover, the nominal clearance of the fluid film, roll, and pitch angles under different working conditions are obtained in terms of the applied load, moments, and polishing velocity. The obtained numerical analysis can be used as guidance for choosing operation parameters in a practical CTMP application.

关键词： numerical analysis     practical CTMP     circular-translational-moving polishing     CTMP     different    

HTML PDF 收藏

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

《医学前沿（英文）》 2022年 第16卷 第4期   页码 551-573 doi: 10.1007/s11684-022-0928-z

摘要： Patients with hepatocellular carcinoma (HCC) and bone metastasis (BM) suffer from greatly reduced life quality and a dismal prognosis. However, BM in HCC has long been overlooked possibly due to its relatively low prevalence in previous decades. To date, no consensus or guidelines have been reached or formulated for the prevention and management of HCC BM. Our narrative review manifests the increasing incidence of HCC BM to sound the alarm for additional attention. The risk factors, diagnosis, prognosis, and therapeutic approaches of HCC BM are detailed to provide a panoramic view of this disease to clinicians and specialists. We further delineate an informative cancer bone metastatic cascade based on evidence from recent studies and point out the main factors responsible for the tumor-associated disruption of bone homeostasis and the formation of skeletal cancer lesions. We also present the advances in the pathological and molecular mechanisms of HCC BM to shed light on translational opportunities. Dilemmas and challenges in the treatment and investigation of HCC BM are outlined and discussed to encourage further endeavors in the exploration of underlying pathogenic and molecular mechanisms, as well as the development of novel effective therapies for HCC patients with BM.

关键词： HCC     bone     osteotropism     clinical     basic researches     advances    

HTML PDF 收藏

Stiffness of a 3-degree of freedom translational parallel kinematic machine

null

《机械工程前沿（英文）》 2014年 第9卷 第3期   页码 233-241 doi: 10.1007/s11465-014-0312-z

摘要：

In this paper, a typical 3-degree of freedom (3-DOF) translational parallel kinematic machine (PKM) is studied and analyzed whose tool platform has only translations along X-, Y- and Z-axes. It consists of three limbs, each of which have arm and forearm with prismatic-revolute-revolute-revolute (PRRR) joints. Inverse kinematics analysis is carried out to find the slider coordinates and joint angles for a given position of tool platform. Stiffness modeling is done based on the compliance matrices of arm and forearm of each limb. Using the stiffness modeling the variations of minimum and maximum translational stiffness in the workspace are analyzed. For various architectural parameters of the 3-DOF PKM the tendency of variations on the minimum and maximum stiffness over the entire workspace is studied; and also the deflections of the tool platform along X, Y, and Z directions with respect to various forces are presented.

关键词： 3-DOF translational PKM     inverse kinematics     stiffness modeling     translational stiffness    

HTML PDF 收藏

Conceptual design of compliant translational joints for high-precision applications

Guangbo HAO,Haiyang LI,Xiuyun HE,Xianwen KONG

《机械工程前沿（英文）》 2014年 第9卷 第4期   页码 331-343 doi: 10.1007/s11465-014-0321-y

摘要：

Compliant translational joints (CTJs) have been extensively used in precision engineering and microelectromechanical systems (MEMS). There is an increasing need for designing higher-performance CTJs. This paper deals with the conceptual design of CTJs via three approaches: parallelogram based method, straight-line motion mechanism based method and combination based method. Typical emerging CTJ designs are reviewed by explaining their design principles and qualitatively analyzing their characteristics. New CTJs are proposed using three approaches, including an asymmetric double parallelogram mechanism with slaving mechanism, several compact and symmetric double parallelogram mechanisms with slaving mechanisms and a general CTJ using the center drift compensation and a CTJ using Roberts linkage and several combination designs. This paper provides an overview of the current advances/progresses of CTJ designs and lays the foundation for further optimization, quantitative analysis and characteristic comparisons.

关键词： compliant mechanisms     translational joints     conceptual design     parallelogram     straight-line motion     combination method    

HTML PDF 收藏

Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

《医学前沿（英文）》 2011年 第5卷 第4期   页码 323-332 doi: 10.1007/s11684-011-0172-4

摘要：
HTML PDF 收藏

Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures

《机械工程前沿（英文）》 2022年 第17卷 第3期 doi: 10.1007/s11465-022-0695-1

摘要： This study presents a family of novel translational parallel mechanisms (TPMs) with single-loop topological structures. The proposed mechanism consists of only revolute and prismatic joints. The novel TPMs are simpler in structure and have fewer joints and components than the well-known Delta Robot. Four types of 2-degree of freedom driving systems are applied to different limb structures to avoid the moving actuator that causes the problem of increased moving mass. Four sample TPMs are constructed using the synthesized limbs, and one of them is investigated in terms of kinematic performance. First, a position analysis is performed and validated through numerical simulation to reveal the characteristics of partially decoupled motion, which improves the controllability of TPM. Second, singular configurations are identified, and the resulting singularity curve is obtained. Lastly, the workspace of TPM is analyzed, and the relationship between the singular configurations and the reachable workspace is explored. The workspace of the 3-CRR (C denotes the cylindrical joint and R denotes the revolute joint) translational mechanism is also presented to prove that the proposed TPM has a fairly large workspace.

关键词： translational parallel mechanism     single loop     multiple driving system     workspace analysis     singularity    

HTML PDF 收藏

Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine

Jisheng Han, Cailian Cui, Liuzhen Wu

《医学前沿（英文）》 2011年 第5卷 第2期   页码 141-150 doi: 10.1007/s11684-011-0136-8

摘要： Drug addiction is a chronic brain disorder characterized by withdrawal symptoms that occur during drug abstinence and a high tendency of relapse. Compared with the currently available pharmacological interventions, acupuncture therapy has the potential to help drug addicts stay away from drugs without major adverse side effects. It has taken decades of research to optimize the parameters of electrical acupoint stimulation for detoxification and for relapse prevention, as well as to establish a safe and easy procedure by which drug addicts can use it on themselves. The discovery that acupuncture can trigger the release of opioid substances from the brain in the 1970s provided the inspiration. Following this, basic research on animals made it possible to understand the mechanisms of action and establish the procedure for treating drug addictions. This article reviews the past, present, and foreseeable future regarding the use of acupuncture-related technique for the treatment of opiate addiction from the perspective of translational medicine.

关键词： morphine     dependence     withdrawal     addiction     dynorphins     acupuncture     electroacupuncture     transcutaneous electrical acupoint stimulation (TEAS)     enkephalins     endorphins    

HTML PDF 收藏

improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational

《医学前沿（英文）》 2022年 第16卷 第5期   页码 745-759 doi: 10.1007/s11684-021-0880-3

摘要： Lingguizhugan Decoction (LGZG) has been investigated in basic studies, with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease (NAFLD). This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting. A randomized, double-blinded, placebo-controlled trial was performed. A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG (two groups: standard dose and low dose) or placebo for 12 weeks on the basis of lifestyle modifications. The primary efficacy variable was homeostasis model assessment of insulin resistance (HOMA-IR). Analyses were performed in two populations in accordance with body mass index (BMI; overweight/obese, BMI ≥ 24 kg/m2; lean, BMI < 24 kg/m 2). For overweight/obese participants, low-dose LGZG significantly decreased their HOMA-IR level compared with placebo (−0.19 (1.47) versus 0.08 (1.99),P = 0.038). For lean subjects, neither dose of LGZG showed a superior effect compared with placebo. Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A (PPP1R3A) and autophagy related 3 (ATG3) significantly increased after LGZG intervention in overweight/obese population. Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD. The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3. Lean subjects may not be a targeted population for LGZG.

关键词： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled trial     DNA N6-methyladenine modification    

HTML PDF 收藏

从农场到微生物工程：微生态与过敏性疾病

Dominique Angèle Vuitton, Jean-Charles Dalphin

《工程（英文）》 2017年 第3卷 第1期   页码 98-109 doi: 10.1016/J.ENG.2017.01.019

摘要：

第二次世界大战之后，IgE 依赖性过敏性疾病的发生呈稳步上升趋势，在人类发展史上，这种现象是很罕见的。许多大规模横断面研究、纵向队列研究及基础实验性研究均指出，在生活方式及生活环境的重大演变过程中人类的一些与过敏相关的“保护性因素”正逐渐消失。其中被广泛认可的观念是：肠道微生态在免疫调节方面扮演着重要角色。本文综述了暴露在不同微生物组成的农场环境对过敏性疾病的保护作用。此外，传统生活环境中的微生物如何促进儿童免疫系统的正常发育，以及此种相互作用在现代生活方式下的不可逆性缺失同样被阐明。“农场效应”的保护作用主要包括：母亲怀孕期间或婴儿期接触动物、谷仓、马厩，饮用未加工的牛奶和其他奶制品。除农场环境中的微生物总量之外，微生物的生物多样性似乎对于这种保护也至关重要，这可能归因于农场环境对机体肠道菌群生物多样性的贡献。过敏性疾病专科医生和儿科医生临床应用传统益生菌(如乳杆菌和双岐杆菌)对过敏性疾病的预防作用并未达到满意的预期效果。小鼠呼吸道过敏性疾病模型研究表明，牛棚中存在着对过敏性疾病起重要预防作用的微生物，如鲁氏不动杆菌(A.lwoffii) F78、乳酸乳球菌(L. lactis) G121 和松鼠葡萄球菌(S.sciuri)W620。然而，在对农场环境的卓有成效的研究基础上，研发新一代益生菌仍需要微生物学家、免疫学家和生物工程师以及儿科医生、过敏性疾病专科医生、临床试验专家和伦理委员会之间的密切合作。

关键词： 过敏     农场     生物多样性     免疫调节     微生态     转化研究    

HTML PDF 收藏

Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

《医学前沿（英文）》 2010年 第4卷 第4期   页码 351-355 doi: 10.1007/s11684-010-0320-2

HTML PDF 收藏

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational

《医学前沿（英文）》 doi: 10.1007/s11684-023-1016-8

摘要： p53 is mutated in half of cancer cases. However, no p53-targeting drugs have been approved. Here, we reposition decitabine for triple-negative breast cancer (TNBC), a subtype with frequent p53 mutations and extremely poor prognosis. In a retrospective study on tissue microarrays with 132 TNBC cases, DNMT1 overexpression was associated with p53 mutations (P = 0.037) and poor overall survival (OS) (P = 0.010). In a prospective DEciTabinE and Carboplatin in TNBC (DETECT) trial (NCT03295552), decitabine with carboplatin produced an objective response rate (ORR) of 42% in 12 patients with stage IV TNBC. Among the 9 trialed patients with available TP53 sequencing results, the 6 patients with p53 mutations had higher ORR (3/6 vs. 0/3) and better OS (16.0 vs. 4.0 months) than the patients with wild-type p53. In a mechanistic study, isogenic TNBC cell lines harboring DETECT-derived p53 mutations exhibited higher DNMT1 expression and decitabine sensitivity than the cell line with wild-type p53. In the DETECT trial, decitabine induced strong immune responses featuring the striking upregulation of the innate immune player IRF7 in the p53-mutated TNBC cell line (upregulation by 16-fold) and the most responsive patient with TNBC. Our integrative studies reveal the potential of repurposing decitabine for the treatment of p53-mutated TNBC and suggest IRF7 as a potential biomarker for decitabine-based treatments.

关键词： p53 mutation     triple-negative breast cancer     decitabine     DNMT1     IRF7     innate immune response    

HTML PDF 收藏

Translational initiatives in thrombolytic therapy

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 1-19 doi: 10.1007/s11684-017-0497-8

摘要：

Once thrombi have formed as part of the pathology defining myocardial infarction, ischemic stroke, peripheral arterial disease, deep venous thrombosis or other embolic disorders, the only clinically meaningful thrombolytic agents available for reversing the thrombogenic process are various plasminogen activators. These agents are enzymes that reverse fibrin polymerization underlying the coagulation process by converting endogenous plasminogen to plasmin, which cleaves the fibrin network to form increasingly smaller protein fragments, a process known as fibrinolysis. For the most part, the major clinically used thrombolytics, tissue plasminogen activator, urokinase and streptokinase, as well as the experimentally investigated agent staphylokinase, are the products of recombinant DNA technology, which permits molecular optimization of clinical efficacy. In all cases of molecular optimization and targeting, however, the primary challenge of thrombolytic therapy remains hemorrhagic side effects, which are especially devastating when they occur intracerebrally. Currently, the best strategy to ameliorate this adverse effect is nanoparticulate encapsulation or complexation, and many strategies of this sort are being actively pursued. This review summarizes the variety of targeted and untargeted thrombolytic formulations that have been investigated in preclinical studies.

关键词： thrombolytics     nanomedicine     plasminogen activators    

HTML PDF 收藏

标题 作者 时间 类型 操作

Overcoming the challenges of conducting translational research in cell therapy

Sowmya Viswanathan, Armand Keating

期刊论文

Translational research on novel drug-eluting stents in percutaneous coronary intervention

Yaling Han, Kai Xu, Chenghui Yan

期刊论文

Error analysis and optimization of a 3-degree of freedom translational Parallel Kinematic Machine

null

期刊论文

Numerical analysis of hydrodynamic process of circular-translational-moving polishing (CTMP)

ZHAI Wenjie, LIU Changxiong, LIANG Yingchun

期刊论文

Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives

期刊论文

Stiffness of a 3-degree of freedom translational parallel kinematic machine

null

期刊论文

Conceptual design of compliant translational joints for high-precision applications

Guangbo HAO,Haiyang LI,Xiuyun HE,Xianwen KONG

期刊论文

Dendritic cell vaccines in cancer immunotherapy: from biology to translational medicine

Hongmei Xu, Xuetao Cao

期刊论文

Design and analysis of partially decoupled translational parallel mechanisms with single-loop structures

期刊论文

Acupuncture-related techniques for the treatment of opiate addiction: a case of translational medicine

Jisheng Han, Cailian Cui, Liuzhen Wu

期刊论文

improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational

期刊论文

从农场到微生物工程：微生态与过敏性疾病

Dominique Angèle Vuitton, Jean-Charles Dalphin

期刊论文

Translational medicine promising personalized therapy in oncology

Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,

期刊论文

Decitabine induces -mediated immune responses in p53-mutated triple-negative breast cancer: a clinical and translational

期刊论文

Translational initiatives in thrombolytic therapy

null

期刊论文